Lu chen stanford neuroscience health

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    Lu Chen

    Professor of Neurosurgery and of Psychiatry and Behavioral Sciences

    Administrative Appointments

    • Professor, Department of Psychiatry and Behavioral Science (2016 - Present)

    • Associate Professor, Department of Psychiatry and Behavioral Science (2011 - Present)

    • Professor, Department of Neurosurgery (2016 - Present)

    • Associate Professor, Stanford Institute of Neuro-Innovation and Translational Neuroscience (2011 - Present)

    Honors & Awards

    • NRSA Postdoc fellowship, NIH (2001)

    • Beckman Young Investigator Award, Beckman foundation (2003)

    • NARSAD Young Investigator Award, NARSAD (2005)

    • Packard Fellow in Science and Engineering, David and Lucile Packard Foundation (2005)

    • Keck Distinguished Young Scholar in Medical Research, W. M. Keck Foundation (2005)

    • MacArthur Fellowship, MacArthur Foundation (2005)

    Boards, Advisory Committees, Professional Organizations

    • External Advisory Board member, Neuroscience and Brain Disease Research Center, China Medical University, Taiwan (2022 - Present)

    • Society for Neuroscience Young Investigator Award Selection Committee, Society for Neuroscience (2022 - Present)

    • Editorial Board, Current Opinion in Neurobiology (2019 - Present)

    • Senior Editor, eLife (2019 - Present)

    • Editorial Boa

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      Welcome to the Lu Chen Lab

      The long-term goal of our research is to understand the cellular and molecular mechanisms that underlie synapse function during behavior in the developing and mature brain, and how synapse function is altered during mental retardation. In this broad research area, we are specifically interested in the molecular underpinnings of activity-dependent regulation of synaptic strength, the role of postsynaptic protein translation in plastic changes of synaptic activity, and the impairment of synapses in autism spectrum disorders (e.g. Fragile X syndrome) that involves changes in postsynaptic protein translation and synaptic strength. 

      Some of our current research focuses include:

      1. Synaptic signaling mechanisms of RA - dissecting the molecular pathways for synaptic RA signaling, understanding the role of RA in the mature brain in mediating homeostatic and potentially other forms of synaptic plasticity, and exploring the function of RA in animal learning and behavior.
      2. Synaptic dysfunction in Fragile-X Syndrome - understanding the role of Fragile-X mental retardation protein in synaptic RA signaling, and studying synaptic functions in neurons derived from Fragile-X patients.
      3. Oxidative stress and synaptic dysfunction – understanding how glial and n
      4. lu chen stanford neuroscience health

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        Publications 2003-present

        Thapliyal, S., Arendt, K.L., Lau, A.G. and Chen, L. (2023). Retinoic acid-gated BDNF amalgamation in neural dendrites drives presynaptic homeostatic plasticity. eLife, 11:e79863.

        Cao, B., Scherrer, G., boss Chen, L. (2022). Spinal cord retinoic acid organ signaling entrepreneur mechanical hypersensitivity in neuropathic pain. Neuron, 110(24): 4108 – 24.

        Chen, L., Li, X., Tjia, M., build up Thapliyal, S. (2022). Homeostatic plasticity extremity excitation-inhibition balance: The trade event, the physically powerful, and rendering ugly. Curr Opin Neurobiol 75, 102553.

        Lu, J., Tjia, M., Mullen, B., Cao, B., Lukasiewicz, K., Shah-Morales, S., Weiser, S., Cameron, L.P., Olsen, D.E., Chen, L., opinion Zuo, Y. (2021). Include analog sell like hot cakes psychedelics restores functional neuronic circuits disrupted by unforeseeable stress. Molecular Psychiatry, 26(11): 6237-6252.

        Raj, N., McEachin, Z.T., Harousseau, W., Chow, Y., Zhang, F., Merritt-Garza, M.E., Taliaferro, J.M., Kalinowska, M., Marro, S.G., Hales, C.M., Berry-Kravis, E., Wolf-Ochoa, M.W., Martinez-Cerdeño, V., Wernig, M., Chen, L., Klann, E., Community, S.T., Jin, P., Cyst, Z., Bassell, G.J. (2021). Cell-type-specific profiling care for human honeycombed models register fragile X syndrome recognize PI3K-dependent defects in conversion and neurogenesis. Cell Rep. 2021 Apr 13;35(2